Search staff/organisations dr.ir. A Schots
Name
Namedr.ir. A Schots
FirstnameArjen
Emailarjen.schots@wur.nl

Job details
DescriptionAssociate Professor
OrganizationDepartment of Plant Sciences
Organization UnitLaboratory of Nematology
Phone+31 6 57558177
Mobile
Secretarial phone+31 317 482 197
Phone 2
Fax+31 317 418 094
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Visiting addressDroevendaalsesteeg 1
6708PB, WAGENINGEN
Building/Room107/W3.Aa.043
Postal addressPostbus 8123
6700ES, WAGENINGEN
Courier123
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Biography

Research conducted by the Laboratory of Nematology is part of the research program of the Graduate School Experimental Plant Sciences (EPS) and the C.T. de Wit Graduate School for Production Ecology & Resource Conservation (PE&RC).

Research:

Plants and Health

In industrialized countries the incidence of inflammatory diseases such as Crohn’s disease, multiple sclerosis, type II diabetes and allergies has risen to 35-40% of the population. People in these countries do not often experience infectious disease due to high hygiene, current vaccinations strategies and medical practices. As a consequence the immune system is insufficiently educated leading to abnormal responses. In our research group we focus on understanding and developing strategies to prevent or combat autoimmune diseases and allergies by (re-)educating the immune system. Our three main research lines are described below.

1. Lessons from parasitic worms. Parasitic worms are master manipulators of the immune system by secreting a variety of proteins. Our aim is to identify these proteins, assess their effect in reducing or steering inflammation and evaluate possibilities for clinical use.

2. Production of immunomodulatory proteins in plants. The plant is an excellent host for the expression of heterologous proteins. We therefore investigate the possibilities to express helminth-secreted proteins that modulate the immune system in tobacco plants. The aim is to use these potential therapeutic proteins to improve or modulate the functioning of our immune system.

3. Helminthisation of the N-glycosylation pathway in plants. Many helminth-secreted proteins are N-glycosylated and often carry typical N-glycan structures. These N-glycan structures have been shown to play an important role in protein activity. Therefore we investigate the possibilities to engineer the N-glycosylation pathway of plants in order to synthesize these helminth-like N-glycan structures. Also, we try to identify and characterise yet unknown helminth glycosyltransferases. Production of N-glycan variants of glycoproteins allows us to study the role of N-glycans types on protein function and interaction with immune cells. For more information on one of the proteins we are currently working on see http://help-t2d.nl.

 

Research group:

  • Kim van Noort

 


Expert Profile
Expertise
Groups
  • Programme Team Plant Sciences

Publications
Key publications
Publication lists

Projects

Projects:

  • Plants produced cytokines
  • The effects of mushrooms on human health

Education

For more information see Education page of our website.

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