The relation between protein fermentation and associated metabolites, microbiota and post-weaning diarrhoea in pigs: STW-DSM partnership, 14935.
Protein fermentation occurs in piglets with post-weaning diarrhoea (PWD). The exact mechanisms behind PWD, however, remain unclear. The aim of this project is to elucidate the relation between protein fermentation, associated metabolites and microbiota, and PWD using an interdisciplinary approach. Firstly, associations between protein fermentation, PWD, metabolites and microbiota are determined by using an on-farm epidemiological approach and taking samples of healthy control and PWD piglets. Secondly, the associations found in phase 1 are tested in vitro in phase 2, by using state of the art 3D organoids and derived 2D monolayers. Finally, an in vivo study is conducted based on the outcome of the previous phases to determine the effects of protein fermentation and/or metabolites on pig performance and (gut) health. This interdisciplinary research will elucidate the relation between protein fermentation and PWD and the effects of metabolites involved in PWD on (gut) health in pigs. This knowledge is required in order to reduce problems with PWD in piglets.