Ecophysiological insights into the human intestinal microbiota
The human intestinal tract consists of trillions of microbes. These microbes have a profound influence on our health. How do more than 1000 bacterial species co-exist in a dense ecosystem is not well known. We also do not have in-depth understanding of the metabolic interactions that occur between the competing and complimenting species. Studying them in their natural ecosystem is technically challenging. We have designed a minimal microbiome that mimics key ecological and metabolic properties of the human microbiome. The minimal microbiome consists of important intestinal microbiota that we identified using publicly available metagenomics datasets. We are currently studying the in-vitro compositional dynamics of the minimal microbiome and furhter we are investigating their functional dynamics using multi-omics as well as basic microbiological assays.
Tools for microbial community analysis
We have developed tools alongwith Dr. Leo Lahti from Open research labs University of Turku for microbial community analysis.
Microbiome R/BioC package tutorials [http://microbiome.github.io/microbiome/]
Microbiomeutilities R package[https://microsud.github.io/microbiomeutilities/articles/microbiomeutilities.html]
Shetty SA, et al. 2017: Intestinal microbiome landscaping: insight in community assemblage and implications for microbial modulation strategies.
For more information contact: Sudarshan A. Shetty; email@example.com