Project title: The role of sirtuin 5 in the response of white adipose tissue to hypoxia.
Project duration: September 2016-September 2020
Hypoxia, also known as low oxygen tension, is a fundamental feature of physiological processes as well as pathophysiological conditions such as obesity, cancer and ischemic diseases. The sufficient cellular adaptive capacity to hypoxia is important for individuals to maintain energy and redox homeostasis, metabolic health even survival under environment challenges.
Sirtuins are highly conserved NAD+ dependent deacylase, and play an important role in energy metabolism under environmental stress by regulating post-transcriptional modifications of diverse metabolic enzymes. Sirt 5 is a recently discovered member of sirtuin family, which is located in mitochondria. There is convincing evidence that sirtuins are involved in adaptive response to hypoxia in healthy individuals. However, little is known about how sirtuin affecting mitochondrial function in response to hypoxia.
Therefore, this reseach aims to study the role of sirt 5 in adaptation to hypoxia. Expect we can supplement some fundamental knowledge to adaptive physiology, and may provide some theoretical basis for therapizing hypoxia-related diseases as well.