Project Title: Whole-cell modeling of Mycoplasma pneumoniae
Project Duration: October 2016 - October 2020
Project Introduction: Mycoplasmas infect not only humans, but a wide range of hosts including pets and farm animals. For most Mycoplasma infections, there is no effective commercial vaccine, which would help preventing diseases, lesions and economic losses.
The MycoSynVac project, starting in 2015, is a collaborative European Project for engineering Mycoplasma pneumoniae, a human respiratory tract pathogen, as a global broad-spectrum animal vaccine. The different goals of the project involve the optimization of large-scale production, the chassis engineering and the vaccine design.
Project aim: The project focuses on: optimization of large-scale production of the vaccine and antigen production through a constraint-based modeling procedure; development and optimization of a biosafety circuit through dynamic modeling approach; construction of a whole-cell dynamic model for Mycoplasma pneumoniae.