Naam
Naam D Zhang
RoepnaamDeli
Emaildeli.zhang@wur.nl

Werk
OmschrijvingUniversitair docent
OrganisatieDepartement Dierwetenschappen
OrganisatieeenheidFysiologie van Mens en Dier
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BezoekadresDe Elst 1
6708WD, WAGENINGEN
Gebouw/Kamer122/E0254
PostadresPostbus 338
6700AH, WAGENINGEN
Bodenummer

Biografie

My long term goal is to prevent and reduce suffering from human cardiac diseases during ageing.

I have a strong focus on transnational research in cardiac heath and a deep motivation in creating and applying novel, cutting-edge technology to human health. In particular, I combine my educational background in molecular genetics (MSc, Sun-Yat Sun University), experimental pharmacology (PhD with distinction cum laude,  University Medical Center Groningen), physiology (Postdoc, Amsterdam UMC location VUmc) with nutrition and (mitochondrial) metabolism (Human and Animal Physiology, Wageningen University), making the perfect combination to achieve my long-term goal.

Atrial fibrillation (AF) is the most common ageing-related arrhythmia, which is associated with significantly increased morbidity and mortality. Over 98% of AF is caused by risk factors including ageing, diabetes, obesity, ischemia and environmental insults. The goal of my current research is to clarify the mechanistic causal links between these risk factors and the pathogenesis of cardiac arrhythmias, in order to develop novel intervention targets to prevent AF. Therefore, my current research line focuses on investigating novel molecular mechanisms by which risk factors promote arrhythmogenesis underlying AF.

Research statement: Arrhythmias can result from abnormal intracellular calcium handling. Emerging evidence suggests that risk factors of AF can modify calcium handling proteins by disturbing the mitochondrial redox homeostasis. Currently, my research is focusing on two areas: 1 ) role of mitochondrial and SR contacts (SMC) in AF pathogenesis and 2) the role of mitochondrial oxidative stress in cardiac arrhythmia. We employ multidisciplinary approaches including electrophysiological studies, biochemical and molecular biological studies, high-resolution and high-speed imaging, bioinformatics analyses, and transcriptomics studies, etc. and utilize cellular, genetically engineered drosophila and mouse models as well as human cardiac samples in our research projects.

This research line is mainly funded by research grants from Dutch heart foundation and Dutch Research Council (NWO-VENI). Some team members also received the fellowship from Chinese Scholarship Council (CSC).


Expertiseprofiel
Expertise
Sociale media
  Deli Zhang op Linkedin
  Deli Zhang op Google Scholar Citations
  Deli Zhang op Twitter

Publicaties
Onderzoeker ID's

Projecten

Preservation the microtubule network to beat atrial fibrillation: Role of SR-mitochondrial contacts
(Project funded by Dutch heart foundation, Dr. Dekker postdoc program)
Targeting stressed mitochondria to prevent diabetes-induced atrial fibrillation
(Project funded by NWO VENI talent program)


Onderwijs
Vakken
  • HAP-32806 - Energy for Life- Molecular Nutritional Physiology of Energy Metabolism
  • HAP-50306 - Model organisms and Research Approaches for Lifespan and Healthspan
  • HNH-34106 - Nutrition and the Ageing Body
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