Zoek medewerkers/organisaties dr. YPY Vermeiren
Naam
Naamdr. YPY Vermeiren
RoepnaamYannick
Emailyannick.vermeiren@wur.nl

Werk
OmschrijvingUniversitair Docent Voeding, Neurochemie & Dementie
OrganisatieDepartement Agrotechnologie en Voedingswetenschappen
OrganisatieeenheidHumane Voeding & Gezondheid
Telefoon+31 317 487 436
Mobiel+31 6 18520620
Telefoon secretariaat+31 317 488 077
Telefoon 2
Fax
Notitie voor telefonist
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BezoekadresStippeneng 4
6708WE, WAGENINGEN
Gebouw/Kamer124/1026
PostadresPostbus 17
6700AA, WAGENINGEN
Bodenummer62
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Ma Di Wo Do Vr
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  • Penningmeester/Treasurer, as part of the Executive Board - Trisomy 21 Research Society (T21RS)
    mei 2021 - apr 2027

    Vanaf 1 mei 2021 ben ik aangesteld als onbezoldig penningmeester van de Trisomie 21 Onderzoeksvereniging (afgekort T21RS; www.t21rs.org), en actief deel van de negen leden van de Raad van Bestuur. De T21RS heeft haar zetel in Groningen, Nederland, en is een wetenschappelijke organisatie zonder winstoogmerk (Algemeen Nut Beogende Instelling; ANBI; KvK n°60501162), met als hoofddoel het stimuleren van onderzoek naar Down syndroom, in de ruimste zin van het woord, naast ook het bevorderen van interactie tussen wetenschappers en patiënten- en familieorganisaties, alsook het bevorderen van opleiding en scholing van jonge onderzoekers en het organiseren van een tweejaarlijks congres. ||From 1 May 2021 onwards I am appointed as an unsalaried treasurer of the Trisomy 21 Research Society (abbreviated T21RS; www.t21rs.org), and thus active as one of the nine Executive Board members. The society has its statutory seat in Groningen in the Netherlands, and is a public benefic organization (ANBI; npo; Chamber of Commerce n°60501162). Its main goal is to stimulate Down syndromes research, provide educational means for young researchers, stimulate interaction between patient and family organizations and scientists, and, organize a biannual international conference. |||

  • Guest Lecturer/Postdoctoral Guest Researcher - Universiteit Antwerpen, Faculteit Geneeskunde, TNW
    dec 2020 - nov 2023

    Unsalaried position at the Faculty of Medicine & Health Sciences, Chair Group of Translational Neurosciences at the University of Antwerp||Research in the domain of (i) Differential diagnosis of dementia-related conditions based on extracellular vesicle-derived biomarkers; (ii) Monoamine-related correlates of behavioral disturbances in neurological disorders |-> (Co)Promotor of 2 PhD-students||One to maximum three (2-4hr) lecture-based classes about (i) the clinical neurochemistry of hypokinetic movement disorders, (ii) aggression, or, related topics mainly to Master students of Biomedical Sciences/Medicine for the courses of Behavioral and Clinical Neurosciences (following invitation - unsalaried)


Biografie

By and large, my ultimate goal in the context of this tenure track trajectory will be to pinpoint neurochemical mechanistic drivers that are inseparable from particular - but most likely modifiable - nutritional habits, shortcomings or deficiencies, in age-related cognitive decline and forthcoming neurodegenerative diseases (NDD; such as Alzheimer's (AD) or Parkinson's disease (PD)), in order to:
(i) unveil novel etiological mechanisms of disease;
(ii) link accompanied behavioral and psychological signs and symptoms of dementia (BPSD);
(iii) provide corrective, potentially-preventive or relieving, and, disease-specific nutritional care.
- - - - - - - - - 
From 2009 until 2015, I gained experience in neurochemical and behavioral research in AD and related NDD (e.g. DLB, PD(D), FTD, ALS, Down syndrome) at the Laboratory of Neurochemistry & Behavior, University of Antwerp (Belgium). Meanwhile, I became coordinator of brain donations to the Neurobiobank of the Institute Born-Bunge (FAGG n° BB190113; Antwerp). We developed and optimized a liquid chromatography method (UHPLC-ECD) for the precise detection of 8 biogenic amines and metabolites in brain, CSF and plasma/serum samples. After my doctoral thesis concerning the neurochemical characterization of behavioral disturbances in dementia, I received the Santkin prize for Alzheimer research (2016; Royal Academy of Medicine, Belgium). Between 2015 and 2020, I became appointed as a postdoctoral guest researcher at the Dept. of Neurology of the UMCG and the Alzheimer Center Groningen (Groningen, Netherlands), and actively became involved in several imaging and bio-analytical projects on early-onset dementia (FTD, ALS) and synucleinopathies. From 2017, after acquiring various grants and a senior FWO-VITO postdoc fellowship (SAO-FRA; Alzheimer Nederland; FWO; JPND (co-applicant)), my neurochemical research line continued and became focused around noradrenergic alterations in DLB and AD patients, as well as Down syndrome subjects with(out) AD, with a special interest into a tiny blueish brainstem nucleus, i.e. the locus coeruleus.
From December 2020 onwards, I will combine my previously acquired research skills in biomarkers of NDD, neurochemistry, behavioral and clinical neurosciences with the study of nutritional alterations in dementia/cognitive decline/ageing as such, at the Wageningen University, Division of Human Nutrition and Health, Chair Group of Nutritional Biology. 

The research I envision is about disease-specific dietary/nutritional interventions in NDD, and, primarily, its preclinical phases, that may have profound effects on the underlying pathophysiology and accompanied behavioral (BPSD), clinical and neurochemical features, with a great deal of attention to revealing causal relationships.

The role of tryptophan, the kynurenine pathway and serotonin across the microbiota-gut-brain axis in elderly at risk of cognitive deterioration and depression will be one of the current topics under investigation (SmartAge-ITN; 2020-2024; ESR10), next to the effect of a 2-year personalized multidomain lifestyle intervention approach to maintain optimal cognitive function in aging (MOCIA/FINGER-NL; 2020-2027).

https://www.uniklinikum-jena.de/etnsmartage/en/ & https://mocia.nl/


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